All through the 1970s, studies by
Cameron, Campbell, and Pauling non-compulsory that high-dose vitamin C has useful
property on quality of life and endurance time in patients with incurable
cancer .However, some ensuing studies—including a randomized, double-blind,
placebo-controlled experimental trial by Mortal and colleagues at the Mayo
Clinic did not bear these findings. In the Mortal study, patients with advanced correctional cancer who received 10 g/day vitamin C fared no better than those getting
a placebo. The authors of a 2003 review assessing the effects of vitamin C in
patients with superior cancer completed that vitamin C confers no significant
mortality benefit Emerging study suggests that the route of vitamin C
administration (intravenous vs. oral) could make clear the conflicting findings
Most intervention trials, together with the one conducted by Mortal and
colleagues, used only oral direction, whereas Cameron and colleagues used a
combination of oral and intravenous (IV) administration. Oral administration of
vitamin C, even of very large doses, can raise plasma vitamin C concentrations
to a most of only 220 micro mole/L, whereas IV administration can make plasma concentration
as high as 26,000 micro mole/L Concentrations of this magnitude are selectively toxicity to tumor cells in nitro .Research in mice suggests that pharmacological
doses of IV vitamin C might show undertake in treating otherwise
difficult-to-treat tumors .A high attention of vitamin C may act as a
pro-oxidant and generate hydrogen peroxide that has selective toxicity toward
cancer cells .Based on these findings and a few case reports of patients with
advanced cancers who had remarkably long endurance times following
administration of high-dose IV vitamin C, some researchers support reassessment
of the use of high-dose IV vitamin C as a drug to treat cancer .As discussed
below, it is uncertain whether supplemental vitamin C and other antioxidants
might interact with chemotherapy and/or energy .Therefore, individuals
undergoing these actions should consult with their oncologist prior to taking
vitamin C or other antioxidant supplements, particularly in high doses .
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